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FACULTÉ DE CHIMIE
UPMC UFR 926

Soutenance de la Thèse de Caleb Medena le 20 octobre 2017

Soutenance de la thèse de Caleb Medena le 20 octobre 2017



Intitulé :

" Synthèse d'hélicènes  énantioenrichis et application en catalyse    asymétrique "

Abstract:

New [6]helicene-based bisphosphinites were synthetized and used in asymmetric catalysis.Desired2,15-dimethoxy[6]helicenes were synthetized by two pathways: photochemical oxidative cyclization and CoI or RhI-catalyzed [2+2+2] cycloaddition. Both enantiomers of [6]Helixols were obtained by preparative chiral HPLC and/or using a chiral agent (up to 99.5 % ee).Even if desired helical cyclic scaffolds cannot be obtained due to the large distance between the two oxygen atoms. The synthesis of new [6]helicenes-based bisphosphinites were developed. Those last were used in gold-catalyzed enantioselective cycloisomerization of 1,6-enynes and Pd-catalyzed asymmetric allylic alkylation.

KEYWORDS: Helicenes – Chirality– Photocyclization – [2+2+2] Cycloaddition – Phosphinites – Ligand – Gold – Palladium – Homogenous asymmetric catalysis

Direction de la faculté de Chimie

T 32 - 42 salle 101

16/11/17

Traductions :

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    24/05/17