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FACULTÉ DE CHIMIE
UPMC UFR 926

Les Mardis de la Chimie "Using a small molecule to elucidate molecular targets for cardiovascular disease in women" le 30 juin 2015Conférence de Tammy Dugas le 30 juin 2015

Dans le cadre des "Mardis de la chimie"

Nous proposons une suite dans 2 semaines par un exposé de la part de
professeur Tammy Dugas de l'université de Louisiane à Bâton Rouge aux
Etats-Unis, avec titre

"Using a small molecule to elucidate molecular targets for cardiovascular
disease in women
"

Cela se déroulera à l'amphi Astier, au bâtiment Esclangon à Jussieu,
le Mardi 30 juin.La conférence sera donnée en anglais. Heure habituelle : 16 h 45 - 18 h avec un thé à 16 h 30.

 

Résumé :

Toxicology is an evolving field of study. With its roots in safetyassessments for environmental or pharmaceutical exposures, modern toxicology
seeks to utilize toxic compounds as tools for the discovery of mechanisms forhuman disease initiation and progression. Thus, modern toxicology research can
facilitate the elucidation of new molecular targets for therapy. A particular casewill be presented in which a small organic compound, 4,4’methylenedianiline,
was found to promote the initiation of a cardiovascular disease known aspulmonary arterial hypertension (PAH), but only in female animals. These findings
are intriguing, in that PAH is a fatal disease that with even the latest therapies, has a poor prognosis, with survival of only ~ 7 years after diagnosis. PAH is >3fold
more prevalent in women than in men. Thus, the finding of female specific disease inthe methylenedianiline exposure model may suggest that elucidating the
mechanism of action of methylenedianiline could prove useful in revealing targets for future therapies. Research suggesting a potential interaction between
methylenedianiline and the estrogen receptor, as well as its ability to alter estrogen metabolism will be discussed, as will the implications of these findings in the
context of human disease pathogenesis and pharmacology.



Alain Frigara - 14/09/16